Disclaimer: The information in the article isn't intended to diagnose, treat or cure any known or unknown disease or illness.

Dangers of Mixing Alcohol and Lisinopril: Interactions & Side Effects

If you're taking lisinopril to manage your high blood pressure, it's essential to take into consideration the risks associated with mixing alcohol and this medication. While moderate drinking may not necessarily cause any harm, excessive alcohol intake can exacerbate the blood-pressure-lowering effects of lisinopril and increase the risk of dangerous side effects.

September 20, 2023

Lisinopril is a popular medication used to treat hypertension and other heart-related conditions. It works by relaxing the blood vessels, allowing the blood to flow more easily through them. While this drug has been widely prescribed and considered safe for use, it's important to understand its potential side effects and how they can be exacerbated when mixed with alcohol.

Let's explore the dangers of mixing alcohol and lisinopril, including their interactions and possible adverse effects on your health.

Understanding Lisinopril

Lisinopril is a medication that is commonly prescribed to treat high blood pressure. It belongs to a class of drugs known as ACE inhibitors, which work by relaxing blood vessels and helping the heart to pump blood more efficiently. This medication is often used in combination with other drugs to achieve optimal blood pressure control.

Side Effects of Lisinopril

While lisinopril is generally safe and well-tolerated, it can cause some side effects in certain individuals. Commonly reported side effects include:

  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Dry cough
  • Skin rash

In rare cases, lisinopril can cause more serious side effects, such as:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Rapid heartbeat
  • Chest pain
  • Fainting

If you experience any of these symptoms while taking lisinopril, you should seek medical attention immediately. It's also important to note that lisinopril can interact with other substances, including over-the-counter medications and herbal supplements. Be sure to inform your healthcare provider of all the medications and supplements you are taking before starting lisinopril.

Mixing Alcohol and Lisinopril: Interactions and Side Effects

Lisinopril is known to have interactions with alcohol, which can cause several serious side effects. The following are some of the risks of mixing alcohol and lisinopril:

1. Increased risk of dizziness, lightheadedness, and fainting

Alcohol can increase the blood pressure-lowering effect of lisinopril, leading to a sudden drop in blood pressure that can cause these symptoms. This effect can be especially dangerous for those who have already experienced a drop in blood pressure due to lisinopril.

2. Liver damage

Both alcohol and lisinopril are metabolized in the liver, and consuming both at the same time can put a strain on the liver. This can lead to liver damage or liver failure, which can be life-threatening.

3. Dehydration

Alcohol is a diuretic, which means it causes the body to lose fluids. When combined with lisinopril, which can also cause dehydration, the risk of severe dehydration increases. Dehydration can cause a range of symptoms, including dizziness, headaches, and confusion.

4. Increased risk of gastrointestinal bleeding

Both alcohol and lisinopril can irritate the lining of the stomach and intestines. Consuming both at the same time can increase the risk of gastrointestinal bleeding, which can cause symptoms like abdominal pain, vomiting blood, and black or tarry stools.

5. Impaired judgment and coordination

Alcohol can impair judgment and coordination, which can be dangerous when combined with lisinopril. People who are taking lisinopril should avoid driving or operating heavy machinery after drinking alcohol.

These risks apply not only to people who regularly drink alcohol but also to those who consume it occasionally or in small amounts. If you're taking lisinopril, it's best to avoid alcohol altogether or to limit your consumption to a moderate amount under the guidance of your healthcare provider.

Effects of Alcohol on Blood Pressure

Alcohol can have various effects on blood pressure, and excessive alcohol intake can increase the risk of hypertension and other cardiovascular problems. While moderate drinking may not necessarily cause any harm, it's important to understand the potential effects of alcohol consumption on blood pressure.

Here are some effects of alcohol on blood pressure:

1. Blood vessel dilation

Alcohol consumption can cause blood vessels to temporarily dilate, leading to a short-term drop in blood pressure. However, this effect is usually short-lived, and as the body metabolizes alcohol, blood pressure tends to rise again.

2. Fluctuations in blood pressure

For people with pre-existing hypertension or other heart conditions, the fluctuation in blood pressure caused by alcohol consumption can be dangerous.

3. Increased risk of hypertension

Excessive alcohol consumption over time can lead to high blood pressure, which increases the risk of cardiovascular problems such as stroke and heart attack.

When taking lisinopril, it's especially important to be aware of the effects of mixing it with alcohol. Both substances work to relax the blood vessels, and combining them can cause a sudden and significant drop in blood pressure. This effect can be particularly risky for those who already have low blood pressure or are taking high doses of lisinopril.

To ensure optimal safety and effectiveness of treatment, it's recommended that you avoid or limit alcohol consumption when taking lisinopril. Your healthcare provider can provide specific guidance based on your individual health status and medication dosage.

Risks Associated with Binge Drinking While Taking Lisinopril

Binge drinking is defined as consuming a large amount of alcohol in a short period of time, typically within two hours. This type of drinking can be particularly risky for those who are taking lisinopril, as it can increase the likelihood of adverse side effects.

When consuming large amounts of alcohol, the liver becomes overwhelmed and cannot process the alcohol as quickly as it's being consumed. This can lead to a buildup of alcohol in the bloodstream, which can exacerbate the blood pressure-lowering effects of lisinopril.

In addition to the risks associated with regular drinking while taking lisinopril, binge drinking can also cause:

  • Severe dehydration
  • Electrolyte imbalances
  • Increased risk of gastrointestinal bleeding
  • Impaired judgment and coordination

These risks are amplified when combined with lisinopril, and can lead to serious health complications if left untreated.

If you're taking lisinopril and plan on consuming alcohol, it's important to do so in moderation and avoid binge drinking at all costs. Your healthcare provider can provide specific guidance on safe levels of alcohol consumption based on your individual health status and medication dosage.

The Impact of Mixing Other Medications with Lisinopril and Alcohol

Lisinopril can interact with a variety of medications, including over-the-counter drugs, prescription medications, and herbal supplements. When mixed with alcohol, these interactions can be intensified and potentially dangerous.

For example, diuretics like furosemide or hydrochlorothiazide are often prescribed alongside lisinopril to manage high blood pressure. When combined with alcohol, the risk of dehydration increases significantly, which can lead to dizziness and fainting.

Other medications that interact with lisinopril include nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin. These drugs can increase the risk of kidney damage when mixed with lisinopril and alcohol.

It's important to always inform your healthcare provider about all the medications you are taking before starting lisinopril. They can advise you on potential interactions and provide guidance on safe alcohol consumption while taking these medications.

What You Can Do to Stay Safe

If you are taking lisinopril, it is important to avoid drinking alcohol. If you do choose to drink, it is important to do so in moderation. This means limiting your intake to one drink per day for women and two drinks per day for men, as recommended by the Centers for Disease Control and Prevention.

It is also important to speak with your doctor about any medications or supplements you are taking before consuming alcohol. Your doctor can advise you on the potential risks and side effects of mixing alcohol with your medications.

Finally, if you experience any unusual symptoms after mixing alcohol and lisinopril, seek medical attention immediately. Symptoms such as dizziness, lightheadedness, and fainting should not be ignored and could be a sign of a serious medical emergency.

Managing High Blood Pressure without Relying on Medication Alone

While medication can be an effective way to manage high blood pressure, there are also lifestyle changes that can help lower your blood pressure and reduce your risk of cardiovascular problems. Here are some tips for managing high blood pressure without relying on medication alone:

1. Maintain a healthy weight

Being overweight or obese can increase your risk of high blood pressure. Losing even a small amount of weight can help lower your blood pressure and improve your overall health.

2. Follow a healthy diet

Eating a diet rich in fruits, vegetables, whole grains, lean protein, and low-fat dairy products can help lower your blood pressure. Avoiding foods that are high in saturated fat, trans fat, and sodium is also important.

3. Exercise regularly

Regular physical activity can help lower your blood pressure and improve your overall health. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.

4. Reduce stress

Chronic stress can contribute to high blood pressure. Finding ways to reduce stress, such as practicing relaxation techniques or engaging in enjoyable activities, can help lower your blood pressure.

5. Limit alcohol consumption

Drinking too much alcohol can raise your blood pressure and increase your risk of cardiovascular problems. If you choose to drink alcohol, do so in moderation.

By making these lifestyle changes, you may be able to manage your high blood pressure without relying solely on medication. However, it's important to talk to your healthcare provider before making any significant changes to your diet or exercise routine.

Alternatives to Drinking Alcohol for Stress and Anxiety

While drinking alcohol is a common way to unwind after a long day, it's not the only option. In fact, there are many alternatives to drinking that can help reduce stress and anxiety levels.

1. Exercise

Regular exercise is an effective way to relieve stress and anxiety. Exercise releases endorphins, which are natural mood elevators. It also helps improve sleep quality, which can further reduce stress levels.

2. Meditation

Meditation is a simple yet powerful technique for reducing stress and anxiety. Practicing meditation regularly can help calm the mind and promote relaxation.

3. Yoga

Yoga combines physical postures with breathing exercises and meditation techniques to promote relaxation and reduce stress. It's a gentle form of exercise that's suitable for people of all fitness levels.

4. Deep breathing

Deep breathing exercises can help slow down the heart rate and lower blood pressure, promoting feelings of calmness and relaxation.

5. Time in nature

Spending time in nature has been shown to have numerous mental health benefits, including reduced stress and anxiety levels. Whether it's taking a walk in the park or going on a hike, spending time in green spaces can be an effective way to unwind.

By incorporating these alternatives into your daily routine, you may find that you're better able to manage your stress and anxiety levels without relying on alcohol. If you're struggling with stress or anxiety, talk to your healthcare provider about other strategies that may be helpful for you.


Mixing alcohol with lisinopril can be dangerous and lead to adverse side effects such as a drop in blood pressure, liver damage, dehydration, gastrointestinal bleeding, and impaired judgment and coordination. Binge drinking while taking lisinopril can exacerbate these risks.

Additionally, alcohol consumption can have various effects on blood pressure, including temporary blood vessel dilation and an increased risk of hypertension over time. It's important to avoid or limit alcohol consumption when taking lisinopril to ensure optimal safety and effectiveness of treatment.

There are lifestyle changes that can help manage high blood pressure without relying solely on medication. Maintaining a healthy weight, following a healthy diet, exercising regularly, reducing stress, and limiting alcohol consumption are all effective ways to lower blood pressure. Alternatives to drinking alcohol for stress and anxiety relief include exercise, meditation, yoga, deep breathing exercises, and spending time in nature.


  • Centers for Disease Control and Prevention. (2021). Moderate Drinking.
  • Mayo Clinic. (2020). High Blood Pressure (Hypertension).
  • National Institute on Alcohol Abuse and Alcoholism. (2014). Harmful Interactions: Mixing Alcohol with Medicines.
  • "Lisinopril and Alcohol: Side Effects and Interactions." Healthline.
  • "Lisinopril." MedlinePlus.
  • "Alcohol and Public Health." Centers for Disease Control and Prevention.

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